1、基本信息
曹朵,女,1990年6月生,陕西延安人。博士,讲师,硕士生导师。
2016年毕业于中国医药工业研究总院,获天然产物化学硕士学位;同年进入西北大学攻读博士学位,2020年12月毕业于西北大学,获中药生物工程博士学位。2019年6月-2020年7月荣获国家公派留学前往英国Aberystwyth大学进行博士联合培养,在此期间主要从事基因组学、蛋白质组学和代谢组学研究;于2021年1月在延安大学生命科学学院工作至今。2022年入选陕西省高校科协青年人才托举计划。
2、研究和招生方向
主要研究方向为中草药天然产物开发利用;主要研究内容:(1)中草药有效物质的分离、纯化和结构鉴定;(2)活性物质生物活性筛选、药效评价及作用机制研究;(3)基因组学、蛋白质组学和代谢组学研究。
招生方向:中药学;天然产物化学;药理学
欢迎药学、细胞生物学、中药学、天然产物化学、药理学及相关专业学生咨询报考。
3、科研项目和学术成果
主持陕西省高校科协青年人才托举计划项目1项、延安大学疫情防控应急科研项目1项目和入选陕西省高校最具转化潜力科技成果项目,参与国际科技合作计划项目1项;近年来在Nanomedicine: Nanotechnology, Biology and Medicine、Drug Delivery、《中草药》等期刊发表论文15余篇,。
(1)主持和参与的项目:
[1]陕西省高校科协青年人才托举计划项目,Serratinine类生物碱抑制RIPK1抗AD的生物活性及作用机制,2023.01~2024.12,主持。
[2]延安大学疫情防控应急科研项目项,新冠肺炎患者恢复期服用方药临床疗效的回顾性分析研究,2022.03~2023.3,陕西省科技厅,主持。
[3]陕西省教育厅国际科技合作计划项目,基于高通量平台的草原毒害草瑞香狼毒的抗菌成分分离鉴定及分子标记开发,2020.01~2021.12,主要参与人。
(2)代表性论文
[1]Cao Duo,et al. Tumor associated macrophages and angiogenesis dual-recognizable nanoparticles for enhanced cancer chemotherapy [J].Nanomedicine: Nanotechnology, Biology and Medicine2018, 14(3):651-659.
[2]Zheng-liang Sun,Duo Cao,et al. PD-1/PD-L1 pathway and angiogenesis dual recognizable nanoparticles for enhancing chemotherapy of malignant cancer [J]Drug Delivery2018, 25(1):1746-1755.
[3]DuoCao, et al. Secondary metabolites of endophytic fungi isolated fromHuperzia serrata[J]Fitoterapia2021,155: 104970.
[4]DuoCao, et al. Pterosin sesquiterpenoids and ent-kaurane diterpenoids from Pterisdactylina Hook [J] Biochemical Systematics and Ecology 2022, 103: 104442.
[5]Duo Cao,et al.Two new highly symmetrical structures from Viscum album [J]Chinese Journal of Natural Medicine2019, 17(2):0145-0148.
[6]Jia-Kun Dai,Duo Cao,et al. Three new bioactive flavonoid glycosides from Viscum album. [J]Chinese Journal of NaturalMedicine2019, 17(7):545-550.
[7]DuoCao,et al. Secondary Metabolites of Endophytic Fungi Isolated fromHuperzia serrata.[J]Fitoterapia2021, 104970: 1-16.
[8]Li, Yan,Duo Cao,et al. Preparation of pesticide microspheres based on polylactic acid: optimized by response surface methodology [J]IOP Conference Series: Materials Science and Engineering2020, 711(1).
[9]Zhenglinag Sun, Huanlong Qin,Duo Cao,et al.Optimization of hydrolysis condition for production and isol of angiotensim-I Converting enzyme inhibition peptides fromRhopilema hispidum[J]Journal of Ocean University of China2018,17(6):1-7.
[10]M Hou, W Hu,D Cao,et al. Ultrasound-Assisted Extraction of Total Flavonoids fromPteris cretica L.: Process Optimization, HPLC Analysis, and Evaluation of Antioxidant Activity [J]Antioxidants2019,8 (10), 425.
[11]Zhang X, Liu S, Wang Y,et al. Interleukin‑22 regulates the homeostasis of the intestinal epithelium during inflammation [J]International journal of molecular medicine2019, 43(4):1657-1668.
[12]K Hao, W Hu, M Hou,D Cao,et al. Optimization of Ultrasonic-Assisted Extraction of Total Phenolics fromCitrus aurantium L. Blossomsand Evaluation of Free Radical Scavenging, Anti-HMG-CoA Reductase Activities [J]Molecules24 (13):2368.
[13]M Hou, W Hu, Z Xiu,et al. Preparative Purification of Total Flavonoids fromSophora tonkinensis Gagnep.by Macroporous Resin Column Chromatography and Comparative Analysis of Flavonoid Profiles by HPLC-PAD [J]Molecules2020, 24(17):3200.
[14]Y Li,D Cao,et al. Preparation of natural pyrethrum-polylactic acid microspheres with different particle sizes and surface morphology [J]Materials Letters2020, 1(13):127345.
[15]M Hou, W Hu,D Cao,et al. Efficient enrichment of total flavonoids fromPteris ensiformis Burm.extracts by macroporous adsorption resins and in vitro evaluation of antioxidant and antiproliferative [J]Journal of Chromatography B2020, 1138:121960.
[16]曹朵;成亮;杨培明. 槲寄生化学成分及药理活性研究进展[J]中草药, 2015, 10:1562.
[17]曹朵;成亮;杨培明. 槲寄生化学成分研究[J]中国医药工业杂志, 2016, 47:861-864.
[18]曹朵;成亮;杨培明. 槲寄生化学成分研究[J]中草药, 2016, 47: 4313-4317.
(3)申请授权专利
发明专利申请:晶体培养法拆分生物碱Serratinine手性异构体的方法及其抗阿尔茨海默氏病应用,(已授权,202010179121.2P)
联系方式
Email:caoduo2013@1163.com
通讯地址:陕西省延安市宝塔区圣地路580号延安大学生命科学学院
邮编:716000