姓 名：杜宏涛

院 系：生命科学学院

职 称：副教授

邮 箱：duhongtao8410@163.com

研究领域：天然活性物质开发与利用

个人简介

化学生物学博士，副教授。主要从事天然活性物质的开发与利用工作，先后完成猪苓、沙枣、骆驼蓬、荨麻等活性物的分离纯化与活性研究。主持和参与国家自然科学基金4项，河南省科技攻关项目1项，药物研发横向项目1项。近年来发表学术论文20余篇，以第一作者或通讯作者在等国际知名期刊发表论文12篇，申请并授权发明专利3项，参编高等教育出版社教材1部。

代表性成果

科研项目：

1.国家自然科学基金青年基金项目《新型鸭嘴花碱类二聚体多靶点抗AD配体的设计、合成及生物活性》

2.河南省科技厅科技攻关项目《脱氧鸭嘴花酮碱-苄基哌嗪衍生物多靶点抗老年痴呆及作用机制研究》

学术论文：

1.Hongtao Du; Fang Ma; Yuanyuan Cao, et al. Bis(7)-harmine derivatives as potential multi-target anti-Alzheimer agents. Frontiers in Chemistry, 2025, 13: 1545908.

2.Hongtao Du; Jinzhi Song; Fang Ma, et al. Novel harmine derivatives as potent acetylcholinesterase and amyloid beta aggregation dual inhibitors for management of Alzheimer’s disease, Journal of Enzyme Inhibition and Medicinal Chemistry, 2023, 38(1): 2281893.

3.Song Xinqiang; Zhang Yu; Du Hongtao. Molecular mechanism of celastrol in the treatment of systemic lupus erythematosus based on network pharmacology and molecular docking technology, Life Sciences, 2020, 117063.

4.Hongtao Du; Xinlian Liu; Jusen Xie, et al. Novel deoxyvasicinone-donepezil hybrids as potential multitarget drug candidates for Alzheimer's disease, ACS Chemical Neuroscience, 2019, 10(5): 2397-2407.

Ma, Fang; Du, Hongtao, Novel deoxyvasicinone derivatives as potent multitarget-directed ligands for the treatment of Alzheimer's disease: Design, synthesis, and biological evaluation, European Journal of Medicinal Chemistry, 2017, 140: 118-127.